Chelerythrine (chloride)

Chelerythrine is a potent, cell permeable inhibitor of protein kinase C (IC50 = 660 nM) that does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase, or calcium/calmodulin-dependent protein kinase. Chelerythrine also inhibits Bcl-xL function (IC50 = 1.5 µM) by displacing Bax binding, inducing apoptosis in several cancer cell lines. Chelerythrine can also have PKC-independent effects, activate p38 MAP kinase and JUNK signaling pathways, and induce apoptosis in cancer cells both in vitro and in vivo.Formal Name: 1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium, monochloride. CAS Number: 3895-92-9. Synonyms: Broussonpapyrine chloride, NSC 646662. Molecular Formula: C21H18NO4 . Cl. Formula Weight: 383.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 0.25 mg/ml. lambdamax: 212, 271, 320, 398 nm. SMILES: COC1=CC=C2C(C=[N+](C)C3=C(C=C(OCO4)C4=C5)C5=CC=C32)=C1OC.[Cl-]. InChi Code: InChI=1S/C21H18NO4.ClH/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22,/h4-10H,11H2,1-3H3,1H/q+1,/p-1. InChi Key: WEEFNMFMNMASJY-UHFFFAOYSA-M.