CH5132799

CH5132799 is an inhibitor of class I PI3K isoforms (IC50s = 14, 120, 500, and 36 nM for PI3Kalpha, PI3Kbeta, PI3Kdelta, and PI3Kgamma, respectively). It is selective for these PI3K isoforms over PI3KC2alpha and PI3KC2beta, which are class II PI3Ks, Vps34, a class III PI3K, and mTOR (IC50s = 5,300, >10,000, >10,000, and 1,600 nM, respectively), as well as 26 additional protein kinases (IC50s = >10,000 nM). CH5132799 inhibits proliferation of HCT116, KPL-4, T47D, and SKOV3 cancer cells expressing the activating mutation PI3KalphaH1047R (IC50s = 200, 32, 56, and 120 nM, respectively). It also reduces tumor growth in a PC3 mouse xenograft model when administered at a dose of 25 mg/kg per day.Formal Name: 5-[6,7-dihydro-7-(methylsulfonyl)-2-(4-morpholinyl)-5H-pyrrolo[2,3-d]pyrimidin-4-yl]-2-pyrimidinamine. CAS Number: 1007207-67-1. Molecular Formula: C15H19N7O3S. Formula Weight: 377.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 12 mg/mL. lambdamax: 276, 337 nm. SMILES: NC(N=C1)=NC=C1C2=NC(N3CCOCC3)=NC4=C2CCN4S(C)(=O)=O. InChi Code: InChI=1S/C15H19N7O3S/c1-26(23,24)22-3-2-11-12(10-8-17-14(16)18-9-10)19-15(20-13(11)22)21-4-6-25-7-5-21/h8-9H,2-7H2,1H3,(H2,16,17,18). InChi Key: JEGHXKRHKHPBJD-UHFFFAOYSA-N.