Cevimeline

Description: Cevimeline, a parasympathomimetic and muscarinic agonist, affects M1 and M3 receptors. Cevimeline has been shown to treat dry mouth and Sj gren's syndrome. It is also used to reduce Xerostomia symptoms and increase salivary flow in head and neck cancer survivors after radiotherapy. Target: Others. Smiles: C[C@@H]1O[C@@]2(CS1)CN1CCC2CC1. References: Barbe AG. Long-term Use of the Sialogogue Medications Pilocarpine and Cevimeline Can Reduce Xerostomia Symptoms and Increase Salivary Flow in Head and Neck Cancer Survivors After Radiotherapy. J Evid Based Dent Pract. 2017 Sep,17(3):268-270. doi: 10.1016/j.jebdp.2017.06.013. Epub 2017 Jul 3. PubMed PMID: 28865825.