Cephalexin

Cephalexin is a cephalosporin antibiotic that is active against most Gram-positive cocci, including penicillinase-producing Staphylococci, and against Gram-negative bacteria such as N. gonorrhoeae, E. coli, K. pneumonia, Salmonellae, Shigella, and some strains of H. influenza. It is not effective against Proteus species, Pseudomonas, or mycobacteria. Cephalexin specifically inactivates penicillin-binding protein (PBP) 3, which is essential for bacterial cell wall synthesis. It has been combined with antibiotics that preferentially target alternate PBP isotypes as a strategy to combat drug-resistant bacteria.Formal Name: (6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. CAS Number: 15686-71-2. Synonyms: Cefalexin. Molecular Formula: C16H17N3O4S. Formula Weight: 347.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: 1 M NH4OH: 25 mg/ml, PBS (pH 7.2): 2 mg/ml. lambdamax: 205, 265 nm. SMILES: O=C(N[C@@H]1C(N2[C@]1([H])SCC(C)=C2C(O)=O)=O)[C@H](N)C3=CC=CC=C3. InChi Code: InChI=1S/C16H17N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1. InChi Key: ZAIPMKNFIOOWCQ-UEKVPHQBSA-N.