Celastrol

Red solid. Soluble in DMSO, ethanol or dimethylformamide. Insoluble in water. Anti-obesity agent. Potent leptin sensitizer, Antioxidant, Potent lipid peroxidation inhibitor, NADPH oxidases (NOX1, 2, 4 and 5) inhibitor, Anti-inflammatory. NF-kappaB inhibitor, HSP90 inhibitor and HSP70 inducer, Anticancer agent. Apoptosis and autophagy inducer. Inhibits PI3K/Akt signaling pathways, Anti-metastatic and anti-angiogenic compound. Reduces VEGFR expression and inhibits HIF-1alpha pathway, Topoisomerase II inhibitor, 20S proteasome chymotrypsin-like activity inhibitor, Potential antiviral and anti-Alzheimer's agent.