Cefoxitin (sodium salt)

Cefoxitin is a cephalosporin antibiotic. It is active against numerous Gram-negative bacteria, including strains of P. mirabilis, P. vulgaris, E. coli, S. typhimurium, and S. enteritidis (MICs = 4-32 µg/ml for all). It binds to B. subtilis penicillin-binding protein 2a (PBP2a), -2b, -3, -4, and -5 (IC50s = 0.72, 0.19, 1.04, 0.14, and 0.19 µg/ml, respectively). Cefoxitin increases survival in mice infected with S. aureus, S. pyogenes, or K. pneumoniae (ED50s = 250, 63, and 795 µg/animal, respectively). Formulations containing cefoxitin have been used in the treatment of bacterial infections.Formal Name: (6R,7S)-3-[[(aminocarbonyl)oxy]methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monosodium salt. CAS Number: 33564-30-6. Synonyms: Betacef, Cenomycin, Farmoxin, Merxin. Molecular Formula: C16H16N3O7S2 . Na. Formula Weight: 449.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.25 mg/ml, DMSO: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 237, 265 nm. SMILES: O=C1[C@](NC(CC2=CC=CS2)=O)(OC)[C@]3([H])N1C(C([O-])=O)=C(COC(N)=O)CS3.[Na+]. InChi Code: InChI=1S/C16H17N3O7S2.Na/c1-25-16(18-10(20)5-9-3-2-4-27-9)13(23)19-11(12(21)22)8(6-26-15(17)24)7-28-14(16)19,/h2-4,14H,5-7H2,1H3,(H2,17,24)(H,18,20)(H,21,22),/q,+1/p-1/t14-,16+,/m1./s1. InChi Key: GNWUOVJNSFPWDD-XMZRARIVSA-M.