Cefotaxime (sodium salt)

Cefotaxime is a cephalosporin antibiotic with potent in vitro activity against streptococcal species, including S. aureus (IC50 = 2 µg/ml) and penicillin-resistant S. pneumoniae. It is also effective against a wide range of other beta-lactamase-producing bacterial species (MIC90s = 0.01 - 130 µg/ml). Cefotaxime acts by interfering with bacterial cell wall synthesis and has also been shown to be a competitive inhibitor of beta-lactamase.Formal Name: (6R)-3-[(acetyloxy)methyl]-7R-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monosodium salt. CAS Number: 64485-93-4. Synonyms: CTX. Molecular Formula: C16H16N5O7S2 . Na. Formula Weight: 477.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 236 nm. SMILES: [H][C@@]1([C@@H]2NC(/C(C3=CSC(N)=N3)=N\OC)=O)N(C(C([O-])=O)=C(COC(C)=O)CS1)C2=O.[Na+]. InChi Code: InChI=1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8,/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26),/q,+1/p-1/b20-9-,/t10-,14-,/m1./s1. InChi Key: AZZMGZXNTDTSME-JUZDKLSSSA-M.