Cefixime

Cefixime is a cephalosporin antibiotic. It is active against numerous Gram-negative bacteria, including clinical isolates of E. coli, K. pneumoniae, and P. mirabilis (MIC90s = 3.13, 0.2, and =0.025 µg/ml, respectively), as well as clinical isolates of the Gram-positive bacteria S. pneumoniae and S. pyogenes (MIC90s = 0.2 and 0.39 µg/ml, respectively). Cefixime is resistant to hydrolysis by beta-lactamases isolated from several bacteria compared to cefaclor (Cay-23626), cephalexin (Cay-9002009), or cefradine (Cay-26060). It increases survival in mice infected with E. coli, K. pneumoniae, or P. mirabilis (ED50s = 0.212, 0.132, and 0.349 mg/kg, respectively). Formulations containing cefixime have been used in the treatment of bacterial infections.Formal Name: (6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-[carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. CAS Number: 79350-37-1. Synonyms: CL-284635, FK-027, FR17027. Molecular Formula: C16H15N5O7S2. Formula Weight: 453.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 0.2 mg/ml. lambdamax: 205, 232, 295 nm. SMILES: [H][C@@]1([C@@H]2NC(/C(C3=CSC(N)=N3)=N\OCC(O)=O)=O)N(C(C(O)=O)=C(C=C)CS1)C2=O. InChi Code: InChI=1S/C16H15N5O7S2/c1-2-6-4-29-14-10(13(25)21(14)11(6)15(26)27)19-12(24)9(20-28-3-8(22)23)7-5-30-16(17)18-7/h2,5,10,14H,1,3-4H2,(H2,17,18)(H,19,24)(H,22,23)(H,26,27)/b20-9-/t10-,14-/m1/s1. InChi Key: OKBVVJOGVLARMR-QSWIMTSFSA-N.