Cefazolin sodium

Description: Cefazolin sodium (cephazolin sodium) salt binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Cefazolin sodium salt is the sodium salt of cefazolin, a beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, which results in the weakening of the bacterial cell wall and cell lysis. Target: Others, Antibacterial, Antibiotic. Smiles: [Na+].Cc1nnc(s1)SCC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)Cn2nnnc2)SC1)C(=O)[O-]. References: Truesdell SE, et al. J Antimicrob ChemOthers. 1989 Apr,23 Suppl D:13-9.