CD38 Inhibitor 1

CD38 inhibitor I is an inhibitor of CD38 (IC50 = 17.7 nM). It is selective for CD38 over poly(ADP-ribose) polymerase 1 (PARP1), sirtuin 1 (SIRT1), and nicotinamide phosphoribosyltransferase (Nampt) when used at a concentration of 100 nM. CD38 inhibitor I (200 nM) increases NAD+ levels in mouse embryonic fibroblasts (MEFs). It decreases glucose and insulin levels in an intraperitoneal glucose tolerance test in 2-year-old, but not 1-year-old or 3-month-old, mice when administered at a dose of 10 mg/kg twice per day. CD38 inhibitor I prevents age-dependent decreases in exercise capacity and physical activity and increases in DNA damage in liver and skeletal muscle in mice.Formal Name: 4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1H)-quinolinone. CAS Number: 1700637-55-3. Synonyms: CD38-IN-78c, CD38 Inhibitor 78c. Molecular Formula: C22H27N3O3S. Formula Weight: 413.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, Ethanol: insol, PBS (pH 7.2): insol. lambdamax: 221, 290 nm. SMILES: CN1C2=CC=C(C3=CN=CS3)C=C2C(N[C@@H]4CC[C@H](CC4)OCCOC)=CC1=O. InChi Code: InChI=1S/C22H27N3O3S/c1-25-20-8-3-15(21-13-23-14-29-21)11-18(20)19(12-22(25)26)24-16-4-6-17(7-5-16)28-10-9-27-2/h3,8,11-14,16-17,24H,4-7,9-10H2,1-2H3/t16-,17-. InChi Key: VJQALSOBHVEJQM-QAQDUYKDSA-N.