CCT007093

CCT007093 is an inhibitor of protein phosphatase 1D (PPM1D, also known as PP2Cdelta and WIP1, IC50 = 8.4 µM), which is encoded by a putative oncogene that is amplified in multiple cancer types. It does not inhibit PPM1A. CCT007093 selectively inhibits the growth of cancer cells that overexpress PPM1D, including MCF-7, KPL-1, and MCF-3B cells, as well as certain ovarian clear cell carcinoma cells. CCT007093 has been used to elucidate the mechanism by which PPM1D drives growth in medulloblastoma cells.Formal Name: 2E,5E-bis(2-thienylmethylene)-cyclopentanone. CAS Number: 176957-55-4. Molecular Formula: C15H12OS2. Formula Weight: 272.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.33 mg/ml, DMSO: 1 mg/ml. lambdamax: 255, 388 nm. SMILES: O=C(/C(CC/1)=C/C2=CC=CS2)C1=C\C3=CC=CS3. InChi Code: InChI=1S/C15H12OS2/c16-15-11(9-13-3-1-7-17-13)5-6-12(15)10-14-4-2-8-18-14/h1-4,7-10H,5-6H2/b11-9+,12-10+. InChi Key: KPFZCKDPBMGECB-WGDLNXRISA-N.