CCR2-RA-[R]

CCR2-RA-[R] is an allosteric antagonist of chemokine (C-C motif) receptor 2 (CCR2, IC50 = 103 nM). It inhibits [35S]GTPgammaS binding and beta-arrestin recruitment induced by chemokine (C-C motif) ligand 2 (CCL2) in U2OS membranes and cells, respectively, expressing CCR2 (IC50s = 24 and 25 nM, respectively).Formal Name: (5R)-4-acetyl-1-(4-chloro-2-fluorophenyl)-5-cyclohexyl-1,5-dihydro-3-hydroxy-2H-pyrrol-2-one. CAS Number: 512177-83-2. Molecular Formula: C18H19ClFNO3. Formula Weight: 351.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 1 mg/ml. lambdamax: 273 nm. SMILES: O=C1C(O)=C(C(C)=O)[C@@H](C2CCCCC2)N1C3=CC=C(Cl)C=C3F. InChi Code: InChI=1S/C18H19ClFNO3/c1-10(22)15-16(11-5-3-2-4-6-11)21(18(24)17(15)23)14-8-7-12(19)9-13(14)20/h7-9,11,16,23H,2-6H2,1H3/t16-/m1/s1. InChi Key: VQNLJXWZGVRLBA-MRXNPFEDSA-N.