CC-223

CC-223 is a potent inhibitor of mTOR (IC50 = 16 nM) that shows selectivity for mTOR over a panel of 246 other kinases. It blocks signaling through both mTORC1 and mTORC2, inhibiting the phosphorylation of S6RP, 4EBP1, and Akt(S473) in cellular systems. CC-223 inhibits growth and induces apoptosis in hematologic and solid tumor cell lines in vitro, and it exhibits dose-dependent tumor growth inhibition in multiple solid tumor xenografts in vivo.Formal Name: 3,4-dihydro-7-[6-(1-hydroxy-1-methylethyl)-3-pyridinyl]-1-(trans-4-methoxycyclohexyl)-pyrazino[2,3-b]pyrazin-2(1H)-one. CAS Number: 1228013-30-6. Molecular Formula: C21H27N5O3. Formula Weight: 397.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/mL, DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL, DMSO: 25 mg/mL, Ethanol: 20 mg/mL. lambdamax: 219, 236, 313, 355 nm. SMILES: CO[C@@H]1CC[C@@H](N2C(CN=C3C2=NC(C4=CN=C(C(O)(C)C)C=C4)=CN3)=O)CC1. InChi Code: InChI=1S/C21H27N5O3/c1-21(2,28)17-9-4-13(10-22-17)16-11-23-19-20(25-16)26(18(27)12-24-19)14-5-7-15(29-3)8-6-14/h4,9-11,14-15,28H,5-8,12H2,1-3H3,(H,23,24)/t14-,15-. InChi Key: UFKLYTOEMRFKAD-SHTZXODSSA-N.