CAY10789

Description: CAY10789 (compound 6) is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist with an IC50 of 2.80 µM and a GPBAR1 (G-protein-coupled bile acid receptor 1) agonist with an EC50 of 3 µM. It significantly decreases U937 cell adhesion to HAEC and reduces TNF-alpha expression. CAY10789 demonstrates promising metabolic stability and excellent pharmacokinetics, making it suitable for studying colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases [1]. Target: Others. Smiles: C(OC1=CC(CO)=CC=C1)C2=NC3=C(C=C2)C=CC=C3