CAY10771

Description: CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor delta (PPARdelta).1It activates FXR and PPARdelta in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 µM, respectively) and is selective for these receptors over retinoic acid receptor alpha (RARalpha), retinoid X receptor alpha (RXRalpha), PPARalpha, PPARgamma, and liver X receptor alpha (LXRalpha) at 10 µM. Target: Others. Smiles: C(OC1=CC(Cl)=C(CNC2=CC=C(CC(O)=O)C=C2)C=C1)C=3C(=NOC3C(C)C)C4=C(Cl)C=CC=C4Cl. References: Schierle, S., Neumann, S., Heitel, P., et al.Design and structural optimization of dual FXR/PPARdelta activatorsJ. Med. Chem.63(15)8369-8379(2020)