CAY10678

Description: CAY10678 is an mPGES-1 inhibitor that inhibits PD-1.CAY10678 reduces collagen deposition and T-cell depletion, and may be used to study melanoma.CASHIPS. Target: PD-1/PD-L1, Prostaglandin Receptor. Smiles: O=C(NC1CCCC1)C2CCN(C3=NC=4C=C(C(=CC4N3C(C)C)C)C)CC2. References: Fukuda Y,et al. Inhibition of Microsomal Prostaglandin E2 Synthase Reduces Collagen Deposition in Melanoma Tumors and May Improve Immunotherapy Efficacy by Reducing T-cell Exhaustion. Cancer Res Commun. 2023 Jul 31,3(7):1397-1408.