CAY10614

Lipid A is a lipid-rich component of endotoxin, also known as lipopolysaccharide (LPS), which in turn is part of the outer membrane of Gram-negative bacteria. Lipid A activates toll-like receptor 4 (TLR4), initiating an immune response. CAY10614 is an antagonist of lipid A activation of TLR4, exhibiting an IC50 value of 1.68 µM in a cell-based assay using modified human embryonic kidney (HEK) cells. It does not significantly affect HEK cell viability. In a model of sepsis, CAY10614 dramatically and significantly improves survival of mice given intraperitoneal LPS.Formal Name: N-cyclopentyl-N,N-dimethyl-3,4-bis(tetradecyloxy)-benzenemethanaminium, iodide. CAS Number: 1202208-36-3. Molecular Formula: C42H78INO2. Formula Weight: 756.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.15 mg/ml, DMSO: 0.14 mg/ml. SMILES: CCCCCCCCCCCCCCOC1=CC=C(C[N+](C)(C)C2CCCC2)C=C1OCCCCCCCCCCCCCC.[I-]. InChi Code: InChI=1S/C42H78NO2.HI/c1-5-7-9-11-13-15-17-19-21-23-25-29-35-44-41-34-33-39(38-43(3,4)40-31-27-28-32-40)37-42(41)45-36-30-26-24-22-20-18-16-14-12-10-8-6-2,/h33-34,37,40H,5-32,35-36,38H2,1-4H3,1H/q+1,/p-1. InChi Key: UXOPVNPWTUWUEA-UHFFFAOYSA-M.