CAY10602

Description: CAY10602 is a SIRT1 activator derived from high throughput screening for compounds that enhance SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays indicate that CAY10602 dose-dependently suppresses NF-kappaB-dependent induction of TNF-alpha by lipopolysaccharide in THP-1 cells, achieving approximately 75% inhibition at 60 µM without cytotoxicity. Target: Sirtuin. Smiles: Nc1c(c2nc3ccccc3nc2n1-c1ccc(F)cc1)S(=O)(=O)c1ccccc1. References: Höppner S, et al. Fragmentation studies of SIRT1-activating drugs and their detection in human plasma for doping control purposes. Rapid Commun Mass Spectrom. 2013 Jan 15,27(1):35-50.