(+)-Catechin (hydrate)

(+)-Catechin is a polyketide synthase-derived polyphenolic flavonoid that has been found in V. vinifera and has diverse biological activities. It inhibits COX-1 (IC50 = 1.4 µM) and lipid peroxidation induced by AAPH (Cay-82235) when used at a concentration of 20 µM. (+)-Catechin inhibits the proliferation of MCF-7, T47D, and MDA-MB-231 breast cancer cells (IC50s = 0.4, 0.1, and 9.3 pM, respectively) and the binding of estradiol to the estrogen receptor (ER) and progesterone receptor (PR) in MCF-7 cells (IC50s = 22.2 and 38.3 pM, respectively).Formal Name: 2R-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3S,5,7-triol, hydrate. CAS Number: 225937-10-0. Synonyms: D-(+)-Catechin, Catechuic Acid, Cyanidol. Molecular Formula: C15H14O6 . XH2O. Formula Weight: 290.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 100 mg/ml, DMSO: 50 mg/ml, Ethanol: 100 mg/ml, PBS (pH 7.2): 1.6 mg/ml. lambdamax: 280 nm. SMILES: OC1=CC([C@@H](O2)[C@@H](O)CC3=C2C=C(O)C=C3O)=CC=C1O.O. InChi Code: InChI=1S/C15H14O6.H2O/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7,/h1-5,13,15-20H,6H2,1H2/t13-,15+,/m0./s1. InChi Key: OFUMQWOJBVNKLR-NQQJLSKUSA-N. Origin: Plant/Tea leaves.