Casein Kinase inhibitor A51

Description: Casein Kinase inhibitor A51 is an orally active casein kinase 1alpha (CK1alpha) inhibitor with anticancer activity that induces apoptosis in leukemia cells, and may be used in the study of neck cancers, acute myeloid leukemia, breast and prostate cancers. Target: Apoptosis, Casein Kinase. Smiles: Cn1ncc(c1CC1CC1)-c1nc(N[C@H]2CC[C@H](N)CC2)ncc1Cl. References: Waleed Minzel, et al. Small Molecules Co-targeting CKIalpha and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models. Cell. 2018 Sep 20,175(1):171-185.e25.