Carviolin

Description: Carviolin is an anthraquinone fungal metabolite that has been found inZ. longicaudatawith immunosuppressive and antitrypanosomal activities.1,2It inhibits LPS- or concanavalin A-induced proliferation of mouse splenocytes (IC50s = 4 and 4.5 µg/ml, respectively).1Carviolin is active againstT. b. brucei(MIC = 41.66 µM).2. Target: Others. Smiles: COc1cc(CO)cc2C(=O)c3cc(O)cc(O)c3C(=O)c12. References: Fujimoto, H., Nakamura, E., Okuyama, E., et al.Six immunosuppressive features from an ascomycete, Zopfiella longicaudata, found in a screening study monitored by immunomodulatory activityChem. Pharm. Bull. (Tokyo)52(8)1005-1008(2004)