Carvacrol

Carvacrol is a monoterpene that has been found in O. vulgare, and has diverse biological activities. It induces currents in HEK293 cells expressing mouse transient receptor potential vanilloid 3 (TRPV3) or rat TRP ankyrin A1 (TRPA1) when used at concentrations of 500 and 250 µM, respectively. It also inhibits constitutive activation of TRP melastatin 7 (TRPM7) expressed in HEK293 cells (IC50 = 306 µM). Carvacrol is active against various strains of P. aeruginosa (MICs = 0.3-0.13 µg/ml) and a variety of plant pathogenic fungi, including A. niger, A. ochraceus, Cladosporium, and F. oxysporum (MICs = 50, 100, 100, and 125 µg/ml, respectively).. It decreases rat brain, liver, and kidney levels of malondialdehyde (MDA), as well as increases superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione reductase (GR), and catalase activities in the same tissues when administered at a dose of 40 mg/kg. Carvacrol (15 mg/kg) decreases the number of liver tumor nodules in a rat model of diethylnitrosamine-induced hepatocarcinogenesis. Formulations containing carvacrol have been used as flavoring agents.Formal Name: 2-methyl-5-(1-methylethyl)-phenol. CAS Number: 499-75-2. Synonyms: Cymophenol, Isopropyl o-cresol, NSC 6188, p-Cymen-2-ol. Molecular Formula: C10H14O. Formula Weight: 150.2. Purity: >98%. Formulation: (Request formulation change), A liquid. Solubility: Chloroform: 10 mg/ml. SMILES: OC1=CC(C(C)C)=CC=C1C. InChi Code: InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4-7,11H,1-3H3. InChi Key: RECUKUPTGUEGMW-UHFFFAOYSA-N. Origin: Synthetic.