Carboplatin

Carboplatin is a platinum-containing DNA-crosslinking agent. It induces the formation of DNA interstrand crosslinks and DNA-protein crosslinks when used at concentrations of 200 and 300 µM. It inhibits the proliferation of GLC-4 small cell lung carcinoma and A2780 and SKOV3 ovarian cancer cells (IC50s = 22.7, 0.5, and 10.2 µM, respectively). Carboplatin reduces tumor growth in an ADJ/PC6 murine plasmacytoma model (ED90 = 0.6 mg/kg, i.p.). Formulations containing carboplatin have been used in the treatment of ovarian cancer.Formal Name: (SP-4-2)-diammine[1,1-cyclobutanedicarboxylato(2-)-kappaO,kappaO'']-platinum. CAS Number: 41575-94-4. Synonyms: CBDCA, CDDCA, cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II), NSC 201345, NSC 241240. Molecular Formula: C6H12N2O4Pt. Formula Weight: 371.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 1 mg/ml. SMILES: O=C([O-][Pt+2]1([NH3])[NH3])C2(CCC2)C([O-]1)=O. InChi Code: InChI=1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6,,,/h1-3H2,(H,7,8)(H,9,10),2*1H3,/q,,,+2/p-2. InChi Key: OLESAACUTLOWQZ-UHFFFAOYSA-L.