Carbamazepine

Carbamazepine is an inhibitor of sodium channels. It preferentially inhibits inactivated voltage-gated sodium channel Nav1.7 and Nav1.3 (IC50s = 406 and 900 µM, respectively) over resting (closed) Nav1.7 and Nav1.3 channels in whole-cell patch-clamp assays using HEK293 cells (IC50s = 1,584 and 2,464 µM, respectively). Carbamazepine (100 µM) inhibits sodium currents in a rat sciatic nerve patch-clamp assay ex vivo. It reduces levels of the endogenous catecholamine dopamine in the striatum and hippocampus, as well as the levels of the dopamine precursor L-DOPA (Cay-13248) in the striatum, in rats when administered at a dose of 100 mg/kg. Dietary administration of carbamazepine (0.5% w/w) reduces amphetamine-induced hyperactivity in mice. It decreases immobility time in the forced swim test in mice when administered in the diet at 0.75% w/w. Formulations containing carbamazepine have been used in the treatment of seizures, trigeminal neuralgia, and bipolar disorder.Formal Name: 5H-dibenz[b,f]azepine-5-carboxamide. CAS Number: 298-46-4. Synonyms: CBZ, NSC 169864. Molecular Formula: C15H12N2O. Formula Weight: 236.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 3 mg/ml. lambdamax: 214, 238, 285 nm. SMILES: NC(N1C2=C(C=CC=C2)C=CC3=C1C=CC=C3)=O. InChi Code: InChI=1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18). InChi Key: FFGPTBGBLSHEPO-UHFFFAOYSA-N.