Captopril

Captopril is an inhibitor of angiotensin-converting enzyme (ACE, IC50 = 23 nM for the rabbit lung enzyme). It inhibits contractions in isolated guinea pig ileal segments induced by angiotensin I or bradykinin (IC50s = 23 and 3 nM, respectively) but not those induced by angiotensin II, histamine, acetylcholine, serotonin (5-HT), or prostaglandin E1 (PGE1, IC50s = >10 µM for all). Captopril (0.1-1 mg/kg) inhibits angiotensin I-induced pressor responses in conscious normotensive rats. It reduces mean blood pressure in two kidney-one clip renal hypertensive (2K-1C) rats and spontaneously hypertensive rats (SHRs). Captopril also reduces cytopathogenicity induced by herpes simplex virus 1 (HSV-1) in SH-SY5Y human neuroblastoma cells. Formulations containing captopril have been used in the treatment of hypertension, congestive heart failure, and diabetic nephropathy.Formal Name: 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-L-proline. CAS Number: 62571-86-2. Synonyms: SA 333, SQ 14,225. Molecular Formula: C9H15NO3S. Formula Weight: 217.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 3 mg/ml. SMILES: OC([C@@H]1CCCN1C([C@H](C)CS)=O)=O. InChi Code: InChI=1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1. InChi Key: FAKRSMQSSFJEIM-RQJHMYQMSA-N. Origin: Synthetic.