Cangrelor (sodium salt)

Cangrelor is an ATP analog that inhibits platelet aggregation (IC50 = 0.4 nM). It is a reversible competitive antagonist of the platelet purinergic P2Y12 receptor. Pretreatment with cangrelor significantly reduces blood clotting induced by ADP in a mouse model of pulmonary thromboembolism. Formulations containing cangrelor have been used to prevent blood clotting in at-risk patients.Formal Name: N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-5'-adenylic acid, anhydride with P,P'-(dichloromethylene)bis[phosphonic acid], tetrasodium salt. CAS Number: 163706-36-3. Synonyms: AR-C69931MX. Molecular Formula: C17H21Cl2F3N5O12P3S2 . 4Na. Formula Weight: 864.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: Soluble. SMILES: O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=C(SCCC(F)(F)F)N=C3NCCSC)O[C@@H]1COP(OP(C(Cl)(Cl)P([O-])([O-])=O)([O-])=O)([O-])=O.[Na+].[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C17H25Cl2F3N5O12P3S2.4Na/c1-43-5-3-23-12-9-13(26-15(25-12)44-4-2-16(20,21)22)27(7-24-9)14-11(29)10(28)8(38-14)6-37-42(35,36)39-41(33,34)17(18,19)40(30,31)32,,,,/h7-8,10-11,14,28-29H,2-6H2,1H3,(H,33,34)(H,35,36)(H,23,25,26)(H2,30,31,32),,,,/q,4*+1/p-4/t8-,10-,11-,14-,,,,/m1..../s1. InChi Key: COWWROCHWNGJHQ-OPKBHZIBSA-J.