CaMKII-IN-1

CaMKII-IN-I is a calcium/calmodulin-dependent kinase II (CaMKII) inhibitor (IC50 = 0.063 µM). It is selective for CaMKII over CaMKIV, myosin light-chain kinase (MLCK), p38alpha, Akt1, and PKC (IC50s = >60, 36, 11, 30, and 21 µM, respectively).Formal Name: 3-chloro-2-methyl-N-[5,6,7,8-tetrahydro-2-[(2-phenylethyl)amino]-6-(phenylmethyl)pyrido[4,3-d]pyrimidin-4-yl]-benzenesulfonamide. CAS Number: 1208123-85-6. Synonyms: Calcium/Calmodulin-dependent Protein Kinase II Inhibitor 1, CaMKII Inhibitor 1. Molecular Formula: C29H30ClN5O2S. Formula Weight: 548.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. lambdamax: 267 nm. SMILES: CC1=C(S(NC2=C3CN(CC4=CC=CC=C4)CCC3=NC(NCCC5=CC=CC=C5)=N2)(=O)=O)C=CC=C1Cl. InChi Code: InChI=1S/C29H30ClN5O2S/c1-21-25(30)13-8-14-27(21)38(36,37)34-28-24-20-35(19-23-11-6-3-7-12-23)18-16-26(24)32-29(33-28)31-17-15-22-9-4-2-5-10-22/h2-14H,15-20H2,1H3,(H2,31,32,33,34). InChi Key: LGUUETDTMQTHML-UHFFFAOYSA-N.