Camalexin

Camalexin is an alkaloid released by plants of the Brassicaceae family in response to pathogen infection. In addition to antimicrobial properties and a role in plant defense, camalexin exhibits antiproliferative activity in vitro against various cancer cell lines. Camalexin is active against HeLa, Jurkat, MDA-MB-231, and CEM cancer cell lines (IC50s = 50.0, 46.2, 77.7, and 67.6 µM, respectively), but it is also toxic to primary human umbilical vein endothelial cells (HUVEC, (IC50 = 74.0 µM). Camalexin induces apoptosis in Jurkat cells by increasing reactive oxygen species (ROS) levels and activating caspase-8 and caspase-9. In human prostate cancer cell lines, camalexin (25 µM) is more active against aggressive lines and increases ROS levels and apoptosis via cathepsin D relocation from lysosomes to the cytosol.Formal Name: 3-(2-thiazolyl)-1H-indole. CAS Number: 135531-86-1. Molecular Formula: C11H8N2S. Formula Weight: 200.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 14 mg/ml, DMSO: 33 mg/ml, DMSO:PBS (pH 7.2) (1:40): 0.02 mg/ml, Ethanol: 10 mg/ml. lambdamax: 217, 319 nm. SMILES: C1(C(C2=NC=CS2)=CN3)=C3C=CC=C1. InChi Code: InChI=1S/C11H8N2S/c1-2-4-10-8(3-1)9(7-13-10)11-12-5-6-14-11/h1-7,13H. InChi Key: IYODIJVWGPRBGQ-UHFFFAOYSA-N.