Calpain Inhibitor III

The calpains are a family of calcium-dependent cysteine proteases that catalyze limited proteolysis of substrates. Calpain Inhibitor III is a cell permeable, selective inhibitor of µ-calpain (calpain-1) and m-calpain (calpain-2). Calpain Inhibitor III crosses the blood-brain barrier to inhibit brain cysteine protease activity and has been reported to have neuroprotective effects in numerous rodent neurotrauma models, including spinal cord injury, cortical impact trauma, neonatal hypoxia-ischemia, and focal cerebral ischemia. Additionally, Calpain Inhibitor III has been shown to attenuate depression in myocardial contractile performance that occurs during reperfusion following cardiac ischemia.Formal Name: N-[(1S)-1-[[(1-formyl-2-phenylethyl)amino]carbonyl]-2-methylpropyl]-carbamic acid, phenylmethyl ester. CAS Number: 88191-84-8. Synonyms: MDL 28170. Molecular Formula: C22H26N2O4. Formula Weight: 382.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 14 mg/ml, DMF:PBS (pH 7) (1:10): 0.09 mg/ml, DMSO: 12.5 mg/ml, Ethanol: 3.3 mg/ml. SMILES: O=C(N[C@@H](C(C)C)C(NC(CC1=CC=CC=C1)C([H])=O)=O)OCC2=CC=CC=C2. InChi Code: InChI=1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19?,20-/m0/s1. InChi Key: NGBKFLTYGSREKK-ANYOKISRSA-N.