Calpain Inhibitor-1

Description: Calpain Inhibitor-1 (compound 36) is a highly potent and selective inhibitor of Calpain 1 (Cal1), a cysteine protease, with an IC50 value of 100 nM and a Ki value of 2.89 µM. Target: Others. Smiles: C(N[C@@H](CC1=CSC=N1)C(NCC2=CN(N=N2)C3=CC=C(F)C=C3)=O)(=O)[C@@H]4[C@@H](C(O)=O)O4. References: Schiefer IT, Tapadar S, Litosh V, et al. Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors. J Med Chem. 2013,56(15):6054-6068.