C53

C53 is a STING agonist. It activates human wild-type STING (EC50 = 185 nM), as well as STING containing the polymorphisms R232, H232, or HAQ in HEK293 cells in an interferon-stimulated gene 54 (ISG54) luciferase reporter assay when used at a concentration of 10 µM. C53 (10 µM) induces the expression of IFN-alpha, IFN-beta, TNF-alpha, chemokine (C-X-C motif) ligand 10 (CXCL10), IL-12p40, and IL-6 in isolated human monocyte-derived dendritic cells (hMO-DCs). It also increases the expression of the dendritic cell markers CD83 and CD86 in hMO-DCs when used at a concentration of 10 µM.Formal Name: 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-1H-indole-6-carboxamide. CAS Number: 2259624-71-8. Synonyms: STING Agonist-12. Molecular Formula: C25H19ClF4N2O2. Formula Weight: 490.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 2 mg/ml, Ethanol: insol, PBS (pH 7.2): insol. lambdamax: 219 nm. SMILES: O=C(C1=CC=C2C(N(CC3=C(F)C=CC=C3Cl)C(C2(C)C)=O)=C1)NCC4=C(F)C=C(F)C=C4F. InChi Code: InChI=1S/C25H19ClF4N2O2/c1-25(2)17-7-6-13(23(33)31-11-15-20(29)9-14(27)10-21(15)30)8-22(17)32(24(25)34)12-16-18(26)4-3-5-19(16)28/h3-10H,11-12H2,1-2H3,(H,31,33). InChi Key: OEBVYNULNKSONR-UHFFFAOYSA-N.