Bruceantin

Bruceantin is a quassinoid originally isolated from B. antidysenterica that has diverse biological activities. It inhibits protein synthesis in HeLa cells, reticulocytes, and reticulocyte lysates (IC50s = 30, 40, and 1,600 nM, respectively). Bruceantin is active against chloroquine-sensitive and -resistant strains of P. falciparum (IC50s = 8 and 13 nM, respectively). It induces apoptosis in HL-60 leukemia and RPMI-8226 multiple myeloma cells (IC50s = 12.2 and 12.8 nM, respectively). Bruceantin (5 mg/kg) induces tumor regression in an RPMI-8226 mouse xenograft model.Formal Name: (11beta,12alpha,15beta)-15-[[(2E)-3,4-dimethyl-1-oxo-2-penten-1-yl]oxy]-13,20-epoxy-3,11,12-trihydroxy-2,16-dioxo-picras-3-en-21-oic acid, methyl ester. CAS Number: 41451-75-6. Synonyms: (-)-Bruceantin, NCI 165563, NSC 165563. Molecular Formula: C28H36O11. Formula Weight: 548.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 222, 280 nm. SMILES: COC([C@]12[C@@]3([H])[C@@]4(CO2)[C@@]([C@H]([C@@H]1O)O)([H])[C@@]5([C@@](C(C)=C(C(C5)=O)O)([H])C[C@@]4([H])OC([C@@H]3OC(/C=C(C)/C(C)C)=O)=O)C)=O. InChi Code: InChI=1S/C28H36O11/c1-11(2)12(3)7-17(30)39-20-22-27-10-37-28(22,25(35)36-6)23(33)19(32)21(27)26(5)9-15(29)18(31)13(4)14(26)8-16(27)38-24(20)34/h7,11,14,16,19-23,31-33H,8-10H2,1-6H3/b12-7+/t14-,16+,19+,20+,21+,22+,23-,26-,27+,28-/m0/s1. InChi Key: IRQXZTBHNKVIRL-GOTQHHPNSA-N. Origin: Plant/Brucea antidysenterica.