BRL-50481

Description: BRL-50481 is a novel and selective PDE7 inhibitor with IC50 values of 0.15 µM for PDE7A, 12.1 µM for PDE7B, 62 µM for PDE4, and 490 µM for PDE3. Target: PDE. Smiles: CN(C)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O. References: Safavi M, et al. New methods for the discovery and synthesis of PDE7 inhibitors as new drugs for neurologicaland inflammatory disorders. Expert Opin Drug Discov. 2013 Jun,8(6):733-51.