BRL 15572

BRL 15572 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT1D (Ki = 0.013 µM in CHO cell membranes expressing the human receptor). It is selective for 5-HT1D over several other G protein-coupled 5-HT receptor subtypes with Ki values ranging from 0.25 to 6.3 µM but does bind 5-HT1A and 5-HT2B receptors (Kis = 0.02 and 0.04 µM, respectively). BRL 15572 also acts as a partial agonist at 5-HT1D receptors (EC50 = 0.008 µM in a [35S]GTPgammaS binding assay).Formal Name: 4-(3-chlorophenyl)-alpha-(diphenymethyl)-1-piperazineethanol, dihydrochloride. CAS Number: 193611-72-2. Molecular Formula: C25H27ClN2O . 2HCl. Formula Weight: 479.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 1 mg/ml. lambdamax: 250, 291 nm. SMILES: OC(C(C1=CC=CC=C1)C2=CC=CC=C2)CN3CCN(C4=CC(Cl)=CC=C4)CC3.Cl.Cl. InChi Code: InChI=1S/C25H27ClN2O.2ClH/c26-22-12-7-13-23(18-22)28-16-14-27(15-17-28)19-24(29)25(20-8-3-1-4-9-20)21-10-5-2-6-11-21,,/h1-13,18,24-25,29H,14-17,19H2,2*1H. InChi Key: WPEXRXMQMPOHIO-UHFFFAOYSA-N.