Bretylium (tosylate)

Bretylium is a class III antiarrhythmic agent and an inhibitor of the Na+/K+-ATPase (IC50 = 4.5 mM). Bretylium also has antiadrenergic activity, inhibiting auricular nerve stimulation-induced vasoconstriction in isolated rabbit ears and hypogastric nerve stimulation-induced contraction of isolated rabbit uterus. It inhibits neuroeffector calcium transients (NCTs), as well as increases action potential delay and the absolute refractory period, but does not inhibit field stimulus-induced CTs in isolated mouse vas deferens sympathetic nerve terminals. Bretylium prevents ventricular fibrillation in anesthetized dogs in a model of sudden coronary death when administered at a dose of 10 mg/kg. Formulations containing bretylium were previously used in the prevention and treatment of ventricular fibrillation.Formal Name: 2-bromo-N-ethyl-N,N-dimethyl-benzenemethanaminium, 4-methylbenzenesulfonate (1:1). CAS Number: 61-75-6. Molecular Formula: C11H17BrN . C7H7O3S. Formula Weight: 414.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 220 nm. SMILES: BrC1=C(C[N+](C)(C)CC)C=CC=C1.CC2=CC=C(S([O-])(=O)=O)C=C2. InChi Code: InChI=1S/C11H17BrN.C7H8O3S/c1-4-13(2,3)9-10-7-5-6-8-11(10)12,1-6-2-4-7(5-3-6)11(8,9)10/h5-8H,4,9H2,1-3H3,2-5H,1H3,(H,8,9,10)/q+1,/p-1. InChi Key: KVWNWTZZBKCOPM-UHFFFAOYSA-M.