BRD6989

BRD6989 is an inhibitor of the Cdk8/cyclin C complex. It selectively binds to the Cdk8/cyclin C complex (IC50 = ~200 nM) over the Cdk1/cyclin B, Cdk2/cyclin A, Cdk5/p35, Cdk7/cyclin H, and Cdk9/cyclin T complexes at 1,000 nM. BRD6989 increases the production of IL-10 in primary mouse bone marrow-derived dendritic cells (BMDCs) stimulated with zymosan A (Cay-21175) with an EC50 value of approximately 1 µM and reduces zymosan A-induced increases in IL-6 levels in the same cells.Formal Name: 2-amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-3-quinolinecarbonitrile. CAS Number: 642008-81-9. Molecular Formula: C16H16N4. Formula Weight: 264.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 5mg/ml. SMILES: N#CC1=C(N)N=C2C(CC(CC2)C)=C1C3=CN=CC=C3. InChi Code: InChI=1S/C16H16N4/c1-10-4-5-14-12(7-10)15(11-3-2-6-19-9-11)13(8-17)16(18)20-14/h2-3,6,9-10H,4-5,7H2,1H3,(H2,18,20). InChi Key: QSYBDNXNOJIKML-UHFFFAOYSA-N.