BRD4 Inhibitor-27

Description: BRD4 Inhibitor-27 is a potent BRD4 inhibitor that inhibits BRD4 BD1 and BRD4 BD2 with IC50s of 9.6 and 11.3 µM, respectively.BRD4 Inhibitor-27 has anticancer activity and can be used for breast cancer research. Target: Epigenetic Reader Domain. Smiles: FC(F)(F)C1=NN=C2C=CC(NCCC3=CNC4=C3C=CC=C4)=NN12. References: Kim JH, et al. Crystal structure of [1,2,4] triazolo[4,3- b ]pyridazine derivatives as BRD4 bromodomain inhibitors and structure-activity relationship study . Sci Rep 13, 10805 (2023).