BQ-788 (sodium salt)

BQ-788 is a peptide endothelin type B (ETB) receptor antagonist (IC50 = 1.2 nM). It is selective for ETB over ETA receptors (IC50 = 280 nM), as well as angiotensin, calcitonin, or neuropeptide receptors at 10 µM. BQ-788 inhibits calcium mobilization induced by endothelin-1 (ET-1) in human Girrardi heart cells (IC50 = 0.54 nM) and vasoconstriction induced by the ETB-selective agonist BQ-3020 in isolated rat pulmonary arteries (pA2 = 8.4). In vivo, BQ-788 (1 mg/kg, i.v.) inhibits ET-1-induced depressor responses and induces pressor responses in rats. It protects against laparotomy and surgical gut handling-induced inhibition of intestinal motility in rats. BQ-788 also attenuates delayed hypotension, vascular hyporeactivity to norepinephrine, and hepatocellular injury and dysfunction in a rat model of LPS-induced endotoxemia.Formal Name: N-[[(2R,6S)-2,6-dimethyl-1-piperidinyl]carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine, monosodium salt. CAS Number: 156161-89-6. Molecular Formula: C34H51N5O7 . Na. Formula Weight: 664.8. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 229, 258, 286, 294 nm. SMILES: C[C@H]1N([C@H](CCC1)C)C(N[C@H](C(N[C@H](CC2=CN(C3=C2C=CC=C3)C(OC)=O)C(N[C@H](CCCC)C(O)=O)=O)=O)CC(C)(C)C)=O.[Na]. InChi Code: InChI=1S/C34H51N5O7.Na/c1-8-9-16-25(31(42)43)35-29(40)26(18-23-20-38(33(45)46-7)28-17-11-10-15-24(23)28)36-30(41)27(19-34(4,5)6)37-32(44)39-21(2)13-12-14-22(39)3,/h10-11,15,17,20-22,25-27H,8-9,12-14,16,18-19H2,1-7H3,(H,35,40)(H,36,41)(H,37,44)(H,42,4. InChi Key: IASLQTYUGYPLFB-FUKQNADPSA-N.