(-)-Borneol

(-)-Borneol is a bicyclic monoterpene originally found in A. canadense. It is a positive allosteric modulator of alpha1beta2gamma2L subunit-containing GABAA receptors with an EC50 value of 237 µM for human recombinant receptors expressed in X. laevis oocytes. It increases the latency to first pentylenetetrazole- and maximal electroshock-induced seizure in mice when administered at doses of 50, 100, and 200 mg/kg. (-)-Borneol (300 mg/kg) also increases the permeability of the blood-brain barrier and increases the concentration of cisplatin reaching tumors in a mouse model of glioblastoma multiforme. Formulations containing (-)-borneol have been used as fragrance ingredients.Formal Name: (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-ol. CAS Number: 464-45-9. Synonyms: L-Borneol, (1S)-(-)-Borneol, endo-(-)-Borneol. Molecular Formula: C10H18O. Formula Weight: 154.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH7.2) (1:2): 0.3 mg/ml, DMSO: 16 mg/ml, Ethanol: 16 mg/ml. SMILES: C[C@@]1(C2(C)C)CC[C@H]2C[C@H]1O. InChi Code: InChI=1S/C10H18O/c1-9(2)7-4-5-10(9,3)8(11)6-7/h7-8,11H,4-6H2,1-3H3/t7-,8+,10+/m0/s1. InChi Key: DTGKSKDOIYIVQL-QXFUBDJGSA-N.