BMS 986299

BMS 986299 is an agonist of the NOD-like receptor protein 3 (NLRP3) inflammasome . It induces IL-1beta secretion from mouse macrophages expressing the human NLRP3 inflammasome (EC50 = 1.28 µM).Formal Name: N-[[4-amino-7-(1H-pyrazol-3-yl)-3H-imidazo[4,5-c]quinolin-2-yl]methyl]-N-ethyl-acetamide. CAS Number: 2242952-69-6. Molecular Formula: C18H19N7O. Formula Weight: 349.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly soluble: 0.1-1 mg/ml, Ethanol: Slightly soluble: 0.1-1 mg/ml, PBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml. SMILES: O=C(C)N(CC)CC1=NC2=C(N1)C3=C(C=C(C4=NNC=C4)C=C3)N=C2N. InChi Code: InChI=1S/C18H19N7O/c1-3-25(10(2)26)9-15-22-16-12-5-4-11(13-6-7-20-24-13)8-14(12)21-18(19)17(16)23-15/h4-8H,3,9H2,1-2H3,(H2,19,21)(H,20,24)(H,22,23). InChi Key: UHNRLQRZRNKOKU-UHFFFAOYSA-N.