BMS-502

Description: BMS-502 is a potent dual inhibitor of diacylglycerol kinase (DGK) alpha and zeta that induces immune responses in human and mouse T cells and blocks intracellular checkpoint signaling in T cells. BMS-502 stimulates immune responses in a dose-dependent manner and can be used to study immune-related diseases. Target: Others. Smiles: N#CC1=NC2=C(N(C)C(C([N+]([O-])=O)=C2N3CCN(C(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F)CC3)=O)C=C1. References: Chupak L, et al. Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization. ACS Med Chem Lett. 2023 Jun 12,14(7):929-935.