BMS 345541 (hydrochloride)

BMS 345541 is a cell permeable inhibitor of the IkappaB kinases IKKalpha and IKKbeta (IC50s = 4 and 0.3 µM). It is without effect against a panel of other serine/threonine and tyrosine kinases at 100 µM. BMS 345541 inhibits signaling through nuclear factor-kappaB (NF-kappaB) both in cells and in vivo, showing excellent pharmacokinetics in mice. It blocks joint inflammation and damage in collagen-induced arthritis in mice and induces apoptosis in melanoma cells both in vitro and in vivo. BMS 345541 is used to explore novel roles for IKK phosphorylation and NF-kappaB signaling.Formal Name: N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine, monohydrochloride. CAS Number: 547757-23-3. Synonyms: IKK Inhibitor III. Molecular Formula: C14H17N5 . HCl. Formula Weight: 291.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. lambdamax: 211, 226, 241, 261, 271, 291, 303, 316, 330 nm. SMILES: CC1=CN=C2N1C3=C(C=CC(C)=C3)N=C2NCCN.Cl. InChi Code: InChI=1S/C14H17N5.ClH/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15,/h3-4,7-8H,5-6,15H2,1-2H3,(H,16,18),1H. InChi Key: MIDKPVLYXNLFGZ-UHFFFAOYSA-N.