BMS-299897

BMS-299897 is an inhibitor of gamma-secretase. It selectively cleaves the carboxy terminal fragment (CTF) of amyloid precursor protein (APP) over the Notch-1 CTF in HEK293 cells (IC50s = 7.1 and 105.9 nM, respectively). BMS-299897 (0.1-1 nmol/animal) reduces increases in amyloid-beta (1-42) (Abeta42) levels induced by Abeta (25-35) in the mouse hippocampus. It also prevents deficits induced by Abeta (25-35) in the novel object recognition test when tested with a one-hour, but not a 24-hour, intertrial interval in the same model.Formal Name: 2-[(1R)-1-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoro-benzenebutanoic acid. CAS Number: 290315-45-6. Molecular Formula: C24H21ClF3NO4S. Formula Weight: 511.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Methanol: soluble. SMILES: C[C@H](C1=C(C=C(C=C1)F)CCCC(O)=O)N(C2=C(C=CC(F)=C2)F)S(=O)(C3=CC=C(C=C3)Cl)=O. InChi Code: InChI=1S/C24H21ClF3NO4S/c1-15(21-11-7-18(26)13-16(21)3-2-4-24(30)31)29(23-14-19(27)8-12-22(23)28)34(32,33)20-9-5-17(25)6-10-20/h5-15H,2-4H2,1H3,(H,30,31)/t15-/m1/s1. InChi Key: IZAOBRWCUGOKNH-OAHLLOKOSA-N.