BLX3887

BLX3887 is an inhibitor of 15-lipoxygenase type 1 (15-LO-1, IC50 = 32 nM in a cell-free enzyme assay). It is selective for 15-LO-1 over 15-LO-2, which it does not inhibit, 5-LO (IC50 = 472 nM), and 12-LO (IC50 = 3,310 nM). BLX3887 inhibits the production of 15-LO metabolites selectively in eosinophils over neutrophils when used at a concentration of 10 µM. It also inhibits endocytosis in, and the migration of, isolated human peripheral blood mononuclear cell-derived dendritic cells in vitro.Formal Name: 4,5-dichloro-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide. CAS Number: 934758-70-0. Synonyms: 15-LO-1 Inhibitor 3887. Molecular Formula: C10H5Cl3FN3O. Formula Weight: 308.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 15 mg/ml, DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml. lambdamax: 260 nm. SMILES: FC1=CC=C(NC(C2=NNC(Cl)=C2Cl)=O)C(Cl)=C1. InChi Code: InChI=1S/C10H5Cl3FN3O/c11-5-3-4(14)1-2-6(5)15-10(18)8-7(12)9(13)17-16-8/h1-3H,(H,15,18)(H,16,17). InChi Key: BEVTYLZKKCIGFB-UHFFFAOYSA-N.