BLU-782

BLU-782 is an inhibitor of activin receptor-like kinase 2 (ALK2) containing an arginine-to-histidine substitution mutation at position 206 (ALK2R206H), an activating mutation found in patients with fibrodysplasia ossificans progressiva (FOP), which is characterized by progressive heterotopic ossification, or diffuse intrinsic pontine glioma (DIPG), which is a type of pediatric brain stem cancer. It binds to ALK2R206H (IC50 = =10 nM) and reduces phosphorylation of the ALK2 substrate SMAD1 at serine 463 (Ser463) and Ser465 in HEK293 cells expressing ALK2R206H (IC50 = =100 nM).Formal Name: 4-[6-[5-[4-ethoxy-1-(1-methylethyl)-4-piperidinyl]-2-pyridinyl]pyrrolo[1,2-b]pyridazin-4-yl]-1-piperazinecarboxylic acid, (3R)-tetrahydro-3-furanyl ester. CAS Number: 2141955-96-4. Synonyms: Activin Receptor-like Kinase 2 Inhibitor 1, ALK2-IN-1, Fidrisertib. Molecular Formula: C31H42N6O4. Formula Weight: 562.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 1 mg/ml. lambdamax: 255, 320 nm. SMILES: CCOC1(C2=CN=C(C3=CN(N=CC=C4N5CCN(CC5)C(O[C@@H]6CCOC6)=O)C4=C3)C=C2)CCN(CC1)C(C)C. InChi Code: InChI=1S/C31H42N6O4/c1-4-40-31(9-12-34(13-10-31)23(2)3)25-5-6-27(32-20-25)24-19-29-28(7-11-33-37(29)21-24)35-14-16-36(17-15-35)30(38)41-26-8-18-39-22-26/h5-7,11,19-21,23,26H,4,8-10,12-18,22H2,1-3H3/t26-/m1/s1. InChi Key: SWVYYNLRVIYURK-AREMUKBSSA-N.