Bizine

Bizine is a phenelzine analog that inhibits lysine-specific demethylase 1 (LSD1, Ki(inact) = 59 nM). It is 23-fold, 63-fold, and >100-fold selective for LSD-1 over monoamine oxidase (MAO) A, MAOB, and LSD2, respectively. Bizine has been shown to induce bulk histone H3 lysine 4 dimethylation in LNCaP cancer cells (EC50 = ~2 µM) and, at 0.5 µM, to protect neurons exposed to oxidative stress.Formal Name: N-[4-(2-hydrazinylethyl)phenyl]-benzenebutanamide. CAS Number: 1591932-50-1. Molecular Formula: C18H23N3O. Formula Weight: 297.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 25 mg/ml, DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml. lambdamax: 246 nm. SMILES: NNCCC(C=C1)=CC=C1NC(CCCC2=CC=CC=C2)=O. InChi Code: InChI=1S/C18H23N3O/c19-20-14-13-16-9-11-17(12-10-16)21-18(22)8-4-7-15-5-2-1-3-6-15/h1-3,5-6,9-12,20H,4,7-8,13-14,19H2,(H,21,22). InChi Key: NTJQPAASNHXPGP-UHFFFAOYSA-N.