Bisindolylmaleimide XI (hydrochloride)

Bisindolylmaleimide XI (BIM XI) is a selective, cell-permeable protein kinase C (PKC) inhibitor that displays 10-fold greater selectivity for PKCalpha (IC50 = 9 nM) and 4-fold greater selectivity for PKCbetaI (IC50 = 28 nM) over Ca2+-independent PKCepsilon (IC50 = 108 nM). Inhibition of PKCalpha by BIM XI and other similar PKC inhibitors has been associated with enhanced cardiac contractility and protection from heart failure. BIM XI prevents T-cell activation and proliferation (with IC50s ranging from 30-150 nM) associated with chronic inflammatory responses in vivo.Formal Name: 3-[8-[(dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione, monohydrochloride. CAS Number: 145333-02-4. Synonyms: BIM XI, Ro 31-0432. Molecular Formula: C28H28N4O2 . HCl. Formula Weight: 489.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: O=C(NC1=O)C(C2=CNC3=C2C=CC=C3)=C1C4=C5N(CCC(CN(C)C)C5)C6=CC=CC=C64.Cl. InChi Code: InChI=1S/C28H28N4O2.ClH/c1-30(2)15-17-12-13-32-22-11-7-5-9-19(22)24(23(32)14-17)26-25(27(33)29-28(26)34)20-16-31(3)21-10-6-4-8-18(20)21,/h4-11,16-17H,12-15H2,1-3H3,(H,29,33,34),1H. InChi Key: HSPRASOZRZDELU-UHFFFAOYSA-N.