BI-639667

BI-639667 is a chemokine (C-C motif) receptor 1 (CCR1) antagonist. It inhibits calcium flux induced by chemokine (C-C motif) ligand 3 (CCL3) in cells expressing CCR1 (IC50 = 2 nM). BI-639667 also inhibits RANTES-induced chemotaxis in THP-1 cells (IC50 = 2 nM).Formal Name: 1-(4-fluorophenyl)-N-[1-[2-(methylsulfonyl)-4-pyridinyl]cyclopropyl]-1H-pyrazolo[3,4-c]pyridine-4-carboxamide. CAS Number: 1295298-26-8. Molecular Formula: C22H18FN5O3S. Formula Weight: 451.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly Soluble: 0.1-1 mg/ml, DMSO: Sparingly Soluble: 1-10 mg/ml. SMILES: FC1=CC=C(N2C(C=NC=C3C(NC4(CC4)C5=CC(S(C)(=O)=O)=NC=C5)=O)=C3C=N2)C=C1. InChi Code: InChI=1S/C22H18FN5O3S/c1-32(30,31)20-10-14(6-9-25-20)22(7-8-22)27-21(29)18-11-24-13-19-17(18)12-26-28(19)16-4-2-15(23)3-5-16/h2-6,9-13H,7-8H2,1H3,(H,27,29). InChi Key: PXQATVYJKMMHAU-UHFFFAOYSA-N.