BGP-15

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. BGP-15 is a PARP inhibitor and insulin sensitizer. In perfused heart, it blocks self-ADP-ribosylation of nuclear PARP (Ki = 57 µM) and mono-ADP-ribosylation of GRP78, resulting in decreased levels of reactive oxygen species, lipid peroxidation, and single-strand DNA breaks. BGP-15 acts as a co-inducer of heat shock protein 72, augmenting expression induced by heat shock factor 1 in adipocytes and skeletal muscles and improving insulin sensitivity.Formal Name: N-[2-hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide, dihydrochloride. CAS Number: 66611-37-8. Molecular Formula: C14H22N4O2 . 2HCl. Formula Weight: 351.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 0.25 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 257, 277 nm. SMILES: N=C(NOCC(O)CN1CCCCC1)C2=CC=CN=C2.Cl.Cl. InChi Code: InChI=1S/C14H22N4O2.2ClH/c15-14(12-5-4-6-16-9-12)17-20-11-13(19)10-18-7-2-1-3-8-18,,/h4-6,9,13,19H,1-3,7-8,10-11H2,(H2,15,17),2*1H. InChi Key: ISGGVCWFTPTHIX-UHFFFAOYSA-N.