Betulinic Acid

Betulinic acid is a natural plant triterpenoid that is structurally related to mammalian bile acids. It is an agonist of the G protein-coupled bile acid receptor TGR5 (EC50 = 1 µM), which might be linked with its ability to alter gene expression and fatty liver development in cells and mice given ethanol. Betulinic acid also reduces NF-kappaB signaling and expression of microRNA-33 in LPS-treated macrophages, increasing levels of the ATP-binding cassette (ABC) cholesterol transporter ABCA1. It also inhibits replication of HIV-1 (IC50 = 1.4 µM) and has cytotoxic effects against cancer cells.Formal Name: 3beta-hydroxy-lup-20(29)-en-28-oic acid. CAS Number: 472-15-1. Synonyms: Lupatic Acid, NSC 113090. Molecular Formula: C30H48O3. Formula Weight: 456.7. Purity: >97%. Formulation: (Request formulation change), A solid. Solubility: DMF: 15 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml, Ethanol: 0.5 mg/ml. SMILES: CC([C@@H]1CC[C@]2(C(O)=O)CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]3([H])[C@]21[H])=C. InChi Code: InChI=1S/C30H48O3/c1-18(2)19-10-15-30(25(32)33)17-16-28(6)20(24(19)30)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h19-24,31H,1,8-17H2,2-7H3,(H,32,33)/t19-,20+,21-,22+,23-,24+,27-,28+,29+,30-/m0/s1. InChi Key: QGJZLNKBHJESQX-FZFNOLFKSA-N. Origin: Plant/Crataeva nurvala Betula alba.